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The Canals of Hering, or intrahepatic bile ductules, are part of the outflow system of exocrine bile product from the liver.
Anatomy
They are found between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.[1][2] Histologically, the cells of the ductule are described as simple cuboidal epithelium, lined partially by cholangiocytes and hepatocytes. They may not be readily visible but can be differentially stained by cytokeratins CK19 and CK7.
Clinical significance
The Canals of Hering are destroyed early in biliary cirrhosis and may be primary sites of scarring in methotrexate toxicity. Research have indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states.[3]
Eponym
They are named for Ewald Hering.[4]
References
- ^ Ross, M.H. & Pawlina, W. 2003. Histology: A Text and Atlas, 4th Edition. Lippincott Williams & Wilkins, Philadelphia.
- ^ Gartner, L.P. & Hiatt, J.L. 2000. Color Atlas of Histology, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
- ^ Saxena, R. & Theise, N. 2004. Canals of Hering: Recent Insights and Current Knowledge, Semin Liver Dis 24: 43-48.
- ^ synd/6168 at Who Named It
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Anatomy of torso, digestive system: Digestive glands |
| Liver |
by region: Left lobe (Caudate lobe, Quadrate lobe) - Right lobe - Transverse fissure of liver
by function (Fibrous capsule of Glisson, Hepatocyte, Space of Disse, Space of Mall, Kupffer cell, Liver sinusoid, Ito cell, Hepatic lobule)
bile ducts: (Bile canaliculus, Canals of Hering, Interlobular bile ducts, Intrahepatic bile ducts, Left and Right hepatic ducts, Common hepatic duct) |
| Gallbladder |
by region (Body, Fundus, Neck)
ducts: Cystic duct |
| Pancreas |
by region (Tail, Body, Head, Uncinate process)
by function (Islets of Langerhans, Exocrine pancreas)
ducts: Pancreatic duct • Accessory pancreatic duct |
| Common |
Common bile duct - Hepatopancreatic ampulla - Sphincter of Oddi |
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