Dorothy Crowfoot Hodgkin
From Wikipedia, the free encyclopedia
Categories: 1910 births | 1994 deaths | Alumni of Somerville College, Oxford | British biochemists | Chancellors of the University of Bristol | Crystallography | Fellows of the Royal Society | Members of the Order of Merit | Nobel laureates in Chemistry | People from Beccles | People from Cairo | Recipients of the Copley Medal | Women chemists
Dorothy Mary Crowfoot Hodgkin, OM, FRS (12 May 1910 – 29 July 1994) was a British founder of protein crystallography. She pioneered the technique of X-ray crystallography, a method used to determine the three dimensional structures of biomolecules. Among her most influential discoveries are the determination of the structure of penicillin and vitamin B12, for which she was awarded the Nobel Prize in Chemistry. In 1969, after 35 years of work and five years after winning the Nobel Prize in Chemistry, Hodgkin was able to decipher the structure of insulin. She is regarded as one of the foremost scientists in the field of X-Ray crystallography studies of natural molecules. Besides her extraordinary scientific abilities, she was unassuming, very communicative, and passionate about social inequalities and peace.
Timeline of her discoveriesHodgkin determined the three-dimensional structures of the following biomolecules:
The list is not exhaustive, it rather highlights major milestones. Early yearsShe was born Dorothy Mary Crowfoot in May 12, 1910 in Cairo, Egypt, to John Crowfoot, excavator and scholar of classics, and Grace Mary Crowfoot née Hood. For the first four years of her life she lived as an English expatriate in Asia Minor, returning to England only a few months each year. She spent the period of World War I in the UK under the care of relatives and friends, but separated from her parents. After the war, her mother decided to stay home in England and educate her children, a period that Hodgkin later described as the happiest in her life. In 1921, she entered the Sir John Leman Grammar School in Beccles, Suffolk. She traveled abroad frequently to visit her parents in Cairo and Khartoum. Both her father and her mother had a strong influence with their Puritan ethic of selflessness and service to humanity which reverberated in her later achievements. Education and researchShe developed a passion for chemistry from a young age, and her mother fostered her interest in science in general. Her excellent early education prepared her well for university. Aged 18, she started studying chemistry at Somerville College, Oxford, then one of the University of Oxford colleges for women only. She also studied at the University of Cambridge under the tutelage of John Desmond Bernal, where she became aware of the potential of X-ray crystallography to determine the structure of proteins. In 1934, she moved back to Oxford and two years later, in 1936, she became a research fellow at Somerville College, a post which she held until 1977. In 1960 she was appointed Wolfson Research Professor at the Royal Society. Insulin structureInsulin was one of her most extraordinary research projects. It began in 1934 when she was offered a small sample of crystalline insulin by Robert Robinson. The hormone captured her imagination because of the intricate and wide-ranging effect it has in the body. However, at this stage X-ray crystallography had not been developed far enough to cope with the complexity of the insulin molecule. She and others spent many years improving the technique. Larger and more complex molecules were being tackled (see timeline above) until in 1969 - 35 years later - the structure of insulin was finally resolved. But her quest was not finished then. She cooperated with other laboratories active in insulin research, gave advice, and travelled the world giving talks about insulin and its importance for diabetes. She considered solving the structure of insulin her greatest scientific achievement. Private lifeHodgkin's scientific mentor J.D. Bernal greatly influenced her life both scientifically and politically. He was a distinguished scientist of great repute in the scientific world, a member of the Communist party, and a faithful supporter of successive Soviet regimes until their invasion of Hungary. She always referred to him as "Sage" and loved and admired him unreservedly; intermittently, they were lovers. The conventional marriages of both Bernal and Hodgkin were far from smooth. In 1937, Dorothy married Thomas Hodgkin who was also a one-time member of the Communist party, as well as a charming, intelligent, energetic and impulsive suitor. She also loved him and always consulted him concerning important problems and decisions. Dorothy bore quietly the many difficulties of these situations. He later had a varied career as a schoolteacher, worker's educationist, historian and economist. He became an advisor in 1961 to Kwame Nkrumah, President of Ghana, where he remained for extended periods, often visited by her. The couple had three children. All three children are still alive today. One has a girl named Alexandra Dorothy after their grandmother. Social activitiesDespite her scientific specialisation and excellence she was by no means a single-minded and one-sided scientist. She received many honours but was more interested in exchange with other scientists. She often employed her intelligence to think about other people's problems and was concerned about social inequalities and stopping conflict. As a consequence she was President of Pugwash from 1976 to 1988. Honours
Apart from the Nobel Prize, she was a recipient of the Order of Merit, a Fellow of the Royal Society, The Lenin Peace Prize, and was Chancellor of Bristol University from 1970 to 1988. References
Obituary notices
External links
ar:دوروثي كراوفوت هودكين ca:Dorothy Crowfoot Hodgkin cs:Dorothy Crowfoot Hodgkin de:Dorothy Mary Hodgkin et:Dorothy Crowfoot Hodgkin es:Dorothy Crowfoot Hodgkin fr:Dorothy Crowfoot Hodgkin gl:Dorothy Crowfoot io:Dorothy Crowfoot Hodgkin id:Dorothy Crowfoot Hodgkin sw:Dorothy Hodgkin nl:Dorothy Crowfoot Hodgkin ja:ドロシー・ホジキン oc:Dorothy Crowfoot Hodgkin pl:Dorothy Crowfoot Hodgkin pt:Dorothy Crowfoot Hodgkin ro:Dorothy Crowfoot Hodgkin sq:Dorothy Crowfoot Hodgkin sk:Dorothy Mary Hodgkinová sl:Dorothy Crowfoot Hodgkin sr:Дороти Кроуфут Хоџкин fi:Dorothy Crowfoot Hodgkin sv:Dorothy Crowfoot Hodgkin tr:Dorothy Crowfoot Hodgkin | ||||||||||||||||||||||||||||||||||||||||||||||||
