Scarlet fever

Scarlet fever is a disease caused by an exotoxin released by Streptococcus pyogenes Group A occurs rarely with impetigo or other streptococcal infections. It is characterized by sore throat, fever, a 'strawberry tongue', and a fine sandpaper rash over the upper body that may spread to cover almost the entire body. Scarlet fever is not rheumatic fever, but may progress into that condition. The rate of development of rheumatic fever in individuals with untreated streptococcal infection is estimated to be 3%. The rate of development is far lower in individuals who have received antibiotic treatment.

Cause

Streptococcus pyogenes (group A streptococcus) is responsible for scarlet fever. It can also cause simple angina, erysipelas, and serious toxin-mediated syndromes like necrotizing fasciitis and the so-called streptococcal toxic shock-like syndrome. The virulence of group A streptococcus seems to be increasing lately. The exanthem, or widespread rash, of scarlet fever is thought to be due to erythrogenic toxin production by specific streptococcal strains in a nonimmune patient. Besides erythrogenic toxins, the Group A streptococcus produces several other toxins and enzymes. Two of the most important are the streptolysins O and S. Streptolysin O, an hemolytic, thermolabile and immunogenic toxin, is the base of the anti-streptolysin O titer, an assay for scarlet fever and erysipelas.

History

This disease was known before the twentieth century as scarlatina (from the Italian scarlattina). Since the middle of the twentieth century the disease has, for reasons which are not understood, become much milder in its effects, and the usage of the name scarlatina has now replaced the term "scarlet fever" in some areas.

Many novels depicting life before the nineteenth century (see Scarlet fever in popular culture below) describe scarlet fever as an acute disease being followed by many months spent in convalescence. The convalescence was probably due to complications with rheumatic fever or even due to the treatments tried. Prior to an understanding of how streptococcus was spread and modern medicine, it was also not uncommon to destroy or burn the personal effects of a person afflicted with scarlet fever to prevent transmission to other people.

Signs and symptoms

Early symptoms indicating the onset of scarlet fever can include: ^{[1] [2]}

• Fever of 37 to 40 degrees C.(101-104 degrees F.)
• Fatigue
• Sore throat
• Headache
• Nausea or Vomiting
• Abdominal pain
• Flushed face with paleness around the mouth (perioral pallor, circumoral pallor)
• Tachycardia (rapid pulse)
• Lymphadenopathy (enlarged lymph nodes)
• Punctate red macules on the hard and soft palate and uvula (Forchheimer spots).
• Bright red tongue with a "strawberry" appearance

• Characteristic rash, which:

• is fine, red, and rough-textured; it blanches upon pressure
• appears 12–48 hours after the fever
• generally starts on the chest, axilla (armpits), and behind the ears
• is worse in the skin folds
• Pastia lines (where the rash becomes confluent in the arm pits and groins) appear and persist after the rash is gone

• The rash begins to fade three to four days after onset and desquamation (peeling) begins. "This phase begins with flakes peeling from the face. Peeling from the palms and around the fingers occurs about a week later and can last up to a month."^[2] Peeling also occurs in axilla, groin, and tips of the fingers and toes.^[1]

  Diagnosis of scarlet fever is clinical. The blood tests shows marked leukocytosis with neutrophilia and conservated or increased eosinophils, high erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), and elevation of antistreptolysin O titer. Blood culture is rarely positive, but the streptococci can usually be demonstrated in throat culture. The complications of scarlet fever include septic complications due to spread of streptococcus in blood and immune-mediated complications due to an aberrant immune response. Septic complications, today rare, include ear and sinus infection, streptococcal pneumonia, empyema thoracis, meningitis and full-blown sepsis, upon which the condition may be called malignant scarlet fever.

  Immune complications include acute glomerulonephritis, rheumatic fever and erythema nodosum. The secondary scarlatinous disease, or secondary malignant syndrome of scarlet fever, includes renewed fever, renewed angina, septic ear, nose, and throat complications and kidney infection or rheumatic fever and is seen around the eighteenth day of untreated scarlet fever.

  Treatment

  Other than the occurrence of the diarrhea, the treatment and course of scarlet fever are no different from those of any strep throat. In case of penicillin allergy, clindamycin or erythromycin can be used with success.

  Scarlet fever in popular culture

  • Little Women by Louisa May Alcott (1868) - Beth contracts scarlet fever, seems to recover, but progresses to rheumatic fever and ultimately succumbs to congestive heart failure.
  • The Velveteen Rabbit by Margery Williams (1922) - The main protagonist, a small boy, contracts scarlet fever and his toys are all burned. Indeed, the velveteen rabbit itself, the boy's favorite toy, was going to be burned by a nurse, but at the book's climax, the toy rabbit comes alive and joins the "real" rabbits outside in the garden.
  • By the Shores of Silver Lake by Laura Ingalls Wilder (1939) - Before the start of the book, Laura's older sister Mary has been left blind by a bout with scarlet fever.
  • All-of-a-Kind Family by Sydney Taylor - Four of the five sisters come down with it, and the house goes under quarantine; no lasting harm to any of the patients.
  • Frankenstein; or, The Modern Prometheus by Mary Wollstonecraft Shelley (1818) - Victor Frankenstein's adoptive sister Elizabeth contracts scarlet fever and recovers. But Victor's mother, who contracts the scarlet fever from Elizabeth, dies.
  • The Witch of Blackbird Pond (1958) by Elizabeth George Spears - A young girl from Barbados is accused of giving scarlet fever to her cousins by using witchcraft.
  • Fever Dream by Ray Bradbury - the young protagonist is diagnosed with scarlet fever, though it appears to mutate into something much more sinister.
  • Private Peaceful by Michael Morpurgo - Molly gets scarlet fever and survives.
  • The first episode of the television show Ozzy & Drix featured a villain named Scarlet Fever, who died after getting sucked into the spleen and shredded.
  • In the 2001 film Osmosis Jones, the main antagonist is a strain of scarlet fever known as "Thrax," whose goal is to "get his own chapter in the medical book" after taking out his host, Frank, in 48 hours. He had the ability to light fire to anything he touched, but was killed when he fell into a jar of rubbing alcohol. Thrax is voiced by Laurence Fishburne.
  • An American soldier in The Steel Helmet lost all of his hair as a child due to Scarlet Fever.
  • Anna Jones, mother of the young Henry 'Indiana' Jones died of Scarlet Fever during the year of 1912.
  • In his novel Survival in Auschwitz, Primo Levi describes his stay at the Auschwitz concentration camp. In the later part of the book^[3], he mentions that he has developed Scarlet fever.

    References

    1. ^ ^{a b} Balentine J and Kessler D (March 7, 2006). "Scarlet Fever". eMedicine. emerg/518. 
    2. ^ ^{a b} Dyne P and McCartan K (October 19, 2005). "Pediatrics, Scarlet Fever". eMedicine. emerg/402. 
    3. ^ Levi, Primo: "Survival in Auschwitz", page 151. Simon & Schuster, 1996

    
    

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